By George F. Vande Woude (ed.), George Klein (ed.)
Quantity sixty one of "Advances in melanoma examine" comprises assurance of the next: molecular ways to melanoma remedy, radiation resistance, melanoma prevention study trials, mammalian gene amplification, retinoblastoma gene functionality, molecular genetic foundation of breast melanoma, and tumour advertising via okadaic acid type compounds.
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G. (1991). A m . J . Clin. Nutr. 53, 251s-259s. This Page Intentionally Left Blank MOLECULAR GENETIC CHANGES IN HUMAN BREAST CANCER Marc J. van de Vijver Department of Pathology, State University Leiden, Postbus 9603, 2300 RC Leiden. The Netherlands 1. Introduction 11. Clinicopathological Aspects of Breast Cancer A. Normal Breast Histology B. Histologic Types of Breast Cancer C. Diagnosis and Treatment 111. Genetic Changes in Human Breast Cancer A. Amplification of Oncogenes B. Point Mutations C.
1991). Whether the association of immunohistochemically detectable p53 staining with the presence of a pointmutated p53 gene is absolute remains to be established. T h e percentage of breast carcinomas positive for p53 nuclear staining is 50-60%. , 1991; P. Devilee and C. Cornelisse, personal communication). In view of these figures, increased levels of p53 protein may also be the result of mechanisms other than p53 gene point mutations. , 1990). , 1991), indicating that the mutation may be an early step in breast cancer development.
The study of 1lq13 region amplification has thus far only been done by Southern blot hybridization of DNA isolated from tumors. Now that two genes are found to be overexpressed at the mRNA level, it may be possible to study overexpression of protein encoded by either the PRAD-1 or the EMS gene. It is hoped that one or both of these proteins can be detected in formalin-fixed, paraffin-embedded tissue and that overexpression is closely correlated to the presence of l l q 1 3 region amplification, as this will open archival tumor material for analysis.