Download Advances in Parasitology, Vol. 66 by David Rollinson, S.I. Hay PDF

By David Rollinson, S.I. Hay

ISBN-10: 0123742293

ISBN-13: 9780123742292

First released in 1963, Advances in Parasitology comprises accomplished and updated reports in all parts of curiosity in modern parasitology. Advances in Parasitology contains clinical experiences on parasites of significant impression, resembling Plasmodium falciparum and trypanosomes. The sequence additionally comprises studies of extra conventional parts, reminiscent of zoology, taxonomy, and lifestyles historical past, which form present pondering and functions. Eclectic volumes are supplemented by way of thematic volumes on a number of themes together with distant Sensing and Geographical details structures in Epidemiology and The Evolution of Parasitism--A phylogenetic persepective.

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In more general terms, the diversity of strains, clinical and parasitological effects, and frequencies of superinfection and reinfection were all seen to vary with the prevalence of infection and intensity of transmission: ‘a single or at most very few strains of parasites would be prevalent where endemicity is at a low level. The acquired immunity will render further clinical activity improbable in the event of homologous re-inoculation . . At higher levels of endemicity the number of strains prevalent may be expected to be greater [and] through repeated reinoculations in the course of time with other strains, the individual’s immunity will become polyvalent to all of the species and strains of parasites which are locally prevalent .

Vivax originating in temperate climates . . similar in all major respects to the pattern of the St. , 1953). Thus ‘the likelihood of secondary attacks may vary with the strain . . [and] New World strains have exhibited a decidedly less frequent tendency to become reactivated after long intervals of quiescence than have the Old World strains’ (Boyd, 1941), a difference that may have arisen because ‘in areas where transmission by mosquitoes can occur during only a short period of each year and where the infective inoculum per patient is often small, strains of P.

The historical study of strain theory provides a basis for framing contemporary debate, but the context of the debate has changed. The genetic bases for resistance to chloroquine and sulphadoxine–pyramethamine are now reasonably well-understood. The questions of infectivity and relapse remain underinvestigated. The goal of distinguishing strains in terms of clinical virulence and immunity remains as elusive as ever, in part because it is now possible to see more genetic variability than is expressed in the phenotype.

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